Article

Selective roles of vertebrate PCF11 in premature and full-length transcript termination

2018-12-09

Abstract excerpt

The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient termination. A key player in this process is the cleavage and polyadenylation (CPA) factor PCF11, which directly binds to the Pol II C-terminal domain and dismantles elongating Pol II from DNA in vitro. We demonstrate that PCF11-mediated termination is essential for vertebrate development. A range of genomic analyses, including: mN...

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Literature Corpus work: 85696bad-5a76-5048-91bd-877c6ec4fe00
DOI: 10.1101/491514

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