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Article

Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition.

Molecular cell - 15 Oct 2015

Fong Nova, Brannan Kristopher, Erickson Benjamin, Kim Hyunmin, Cortazar Michael A, Sheridan Ryan M, Nguyen Tram, Karp Shai, Bentley David L

Abstract excerpt

The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the 5'PO4-end exposed by nascent RNA cleavage and chases down the RNA polymerase. We tested this mechanism using a dominant-negative human Xrn2 mutant and found that it delayed termination genome-wide. Xrn2 nuclease inactivation caused strong termination defects downstream of most poly(A) sites and modest delays at some...

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Identifiers

PMID: 26474067
DOI: 10.1016/j.molcel.2015.09.026
PMCID: PMC4654110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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