Article
The landscape of RNA Pol II binding reveals a stepwise transition during ZGA.
Nature - 1 Nov 2020
Liu Bofeng, Xu Qianhua, Wang Qiujun, Feng Su, Lai Fangnong, Wang Peizhe, Zheng Fangyuan, Xiang Yunlong, Wu Jingyi, Nie Junwei, Qiu Cui, Xia Weikun, Li Lijia, Yu Guang, Lin Zili, Xu Kai, Xiong Zhuqing, Kong Feng, Liu Ling, Huang Chunyi, Yu Yang, Na Jie, Xie Wei
Abstract excerpt
Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc-seq), we investigated the landscapes of RNA polymerase II (Pol II) binding in mouse embryos. We found that Pol II undergoes 'loading', 'pre-configuration', and...
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