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Article

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.

Molecular cell - 4 Nov 2021

Hu Shibin, Peng Linna, Xu Congling, Wang Zhenning, Song Aixia, Chen Fei Xavier

Abstract excerpt

Transcription progression is governed by multitasking regulators including SPT5, an evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer activation to termination. Here we utilize a rapid degradation system and reveal crucial functions of SPT5 in maintaining cellular and chromatin RNA polymerase II (Pol II) levels. Rapid SPT5 depletion causes a pronounced reduction of...

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Share to Antigens, Differentiation, B-Lymphocyte
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Histocompatibility Antigens Class II

Share to Regulatory Sequences, Nucleic Acid

Share to RNA Polymerase II

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Share to Transcriptional Elongation Factors

Source

Identifiers

PMID: 34534457
DOI: 10.1016/j.molcel.2021.08.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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