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Article

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.

Cell - 27 Apr 2012

Jenal Mathias, Elkon Ran, Loayza-Puch Fabricio, van Haaften Gijs, Kühn Uwe, Menzies Fiona M, Oude Vrielink Joachim A F, Bos Arnold J, Drost Jarno, Rooijers Koos, Rubinsztein David C, Agami Reuven

Abstract excerpt

Alternative cleavage and polyadenylation (APA) is emerging as an important layer of gene regulation. Factors controlling APA are largely unknown. We developed a reporter-based RNAi screen for APA and identified PABPN1 as a regulator of this process. Genome-wide analysis of APA in human cells showed that loss of PABPN1 resulted in extensive 3' untranslated region shortening. Messenger RNA transcription, stability...

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Share to 3' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation

Share to Muscular Dystrophy, Oculopharyngeal

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Source

Identifiers

PMID: 22502866
DOI: 10.1016/j.cell.2012.03.022

Genes

PABPN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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