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Article

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity.

Genes & development - 15 Jan 2018

Eaton Joshua D, Davidson Lee, Bauer David L V, Natsume Toyoaki, Kanemaki Masato T, West Steven

Abstract excerpt

Termination is a ubiquitous phase in every transcription cycle but is incompletely understood and a subject of debate. We used gene editing as a new approach to address its mechanism through engineered conditional depletion of the 5' → 3' exonuclease Xrn2 or the polyadenylation signal (PAS) endonuclease CPSF73 (cleavage and polyadenylation specificity factor 73). The ability to rapidly control Xrn2 reveals a...

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Identifiers

PMID: 29432121
DOI: 10.1101/gad.308528.117
PMCID: PMC5830926

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