Article

Proximity of pre-mRNA 3′ end processing and transcription termination predicts enhanced gene expression

2025-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Two key factors required for pre-mRNA 3’ end cleavage and polyadenylation, CPSF73 and PCF11, exhibit oncogenic properties: their elevated expression is associated with poor cancer patient prognosis. However, both proteins are also transcription termination factors, and it is unclear which of the processes they promote might contribute to carcinogenesis. Here, we employ a cellular model of colore...

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Literature Corpus work: 162c32dd-ea19-5449-b340-fd495c0a2659
DOI: 10.64898/2025.12.02.691783

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