Article

Termination dynamics set RNAPII elongation rate and gate the response to CDK12 inactivation

2026-07-21

Abstract excerpt

<h4>ABSTRACT</h4> The transcriptional fidelity of RNA polymerase II (RNAPII) is governed by a tight equilibrium between elongation and termination activities, a balance frequently disrupted in human diseases such as cancer. The transcriptional cyclin-dependent kinase 12 (CDK12) maintains RNAPII elongation rate and processivity throughout the gene body. Inactivation of CDK12 disrupts this homeostatic balance and c...

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Literature Corpus work: d12d31be-9409-5528-ac2a-2ea9ed37ec66
DOI: 10.64898/2026.07.20.737372

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