Article

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

2023-03-07

Abstract excerpt

<h4>ABSTRACT</h4> Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown. In this study, we generate Hi-C and ChIP-seq data and compare TAD organization across four primate and four rodent species, and characterize the genet...

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Literature Corpus work: 0b0c01a6-47ab-5c5b-a47c-6bc992982679
DOI: 10.1101/2023.03.07.531534

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