Article
Topologically associating domain boundaries are required for normal genome function.
Communications biology - 20 Apr 2023
Rajderkar Sudha, Barozzi Iros, Zhu Yiwen, Hu Rong, Zhang Yanxiao, Li Bin, Alcaina Caro Ana, Fukuda-Yuzawa Yoko, Kelman Guy, Akeza Adyam, Blow Matthew J, Pham Quan, Harrington Anne N, Godoy Janeth, Meky Eman M, von Maydell Kianna, Hunter Riana D, Akiyama Jennifer A, Novak Catherine S, Plajzer-Frick Ingrid, Afzal Veena, Tran Stella, Lopez-Rios Javier, Talkowski Michael E, Lloyd K C Kent, Ren Bing, Dickel Diane E, Visel Axel, Pennacchio Len A
Abstract excerpt
Topologically associating domain (TAD) boundaries partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotypes1-3, but the overall extent to which this occurs remains unknown. Here we demonstrate that targeted deletions of TAD boundaries cause a range of disruptions to normal in vivo genome...
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