Article

Active enhancers strengthen insulation by RNA-mediated CTCF binding at TAD boundaries

2021-07-14

Abstract excerpt

Vertebrate genomes are partitioned into Topologically Associating Domains (TADs), which are typically bound by head-to-head pairs of CTCF binding sites. Transcription at TAD boundaries correlates with better insulation, however, it is not known whether the boundary transcripts themselves contribute to boundary function. Here we characterize boundary-associated RNAs genome-wide, focusing on the disease-relevant IN...

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Literature Corpus work: 2018b3d9-4d21-55b0-8c1e-df643e9eee96
DOI: 10.1101/2021.07.13.452118

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