Article

Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function

2021-05-07

Abstract excerpt

<h4>Summary</h4> Topologically associating domain (TAD) boundaries are thought to partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotype 1–3 , but the overall extent to which this occurs remains unknown. Here we show that TAD boundary deletions commonly disrupt normal genome function in vi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 488c38b2-602c-5f18-8f8e-db1869211183
DOI: 10.1101/2021.05.06.443037

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Topologically Associating Domain Boundaries are Commonly Required for Normal Genome FunctionDOI 10.1101/2021.05.06.443037Read

Topologically associating domain boundaries are required for normal genome function.Semantic proximity Read

When TADs go bad: chromatin structure and nuclear organisation in human diseaseSemantic proximity Read

Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and developmentSemantic proximity Read

Breaking TADs: How Alterations of Chromatin Domains Result in Disease.Semantic proximity Read

Chromatin accessibility classification of TAD boundaries discloses new architectural proteinsSemantic proximity Read

Topologically associating domain (TAD) boundaries stable across diverse cell types are evolutionarily constrained and enriched for heritabilitySemantic proximity Read

Active enhancers strengthen insulation by RNA-mediated CTCF binding at TAD boundariesSemantic proximity Read

Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability.Semantic proximity Read

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and functionSemantic proximity Read

Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion MachinerySemantic proximity Read

Evolutionary stability of topologically associating domains is associated with conserved gene regulationSemantic proximity Read

Lessons from the analysis of TAD boundary deletions in normal populationSemantic proximity Read