Article

CXXC1 is redundant for normal DNA double-strand break formation and meiotic recombination in mouse

2018-04-20

Abstract excerpt

In most mammals, including mice and humans, meiotic recombination is determined by the meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences and trimethylates histone 3 at lysine-4 and lysine-36 at the adjacent nucleosomes. These actions ensure successful DNA double strand break initiation and repair that occur on the proteinaceous structure forming the chromosome axis. The process...

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Literature Corpus work: 8539fad3-f61c-54e0-9f80-cfc7e097f132
DOI: 10.1101/305508

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