Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination

27 Oct 2023

Abstract excerpt

The formation of RAD51/DMC1 filaments on single-stranded (ss)DNAs essential for homology search and strand exchange in DNA double-strand break (DSB) repair is tightly regulated. FIGNL1 AAA+++ ATPase controls RAD51-mediated recombination in human cells. However, its role in gametogenesis remains unsolved. Here, we characterized a germ line-specific conditional knockout (cKO) mouse of FIGNL1. Fignl1 cKO male mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics and Chromatin Dynamics
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37891173
DOI: 10.1038/s41467-023-42576-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombinationPMID 37891173Read ↗

The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loadingSemantic proximity Read ↗

FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loadingSemantic proximity Read ↗

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restartSemantic proximity Read ↗

Homologous recombinational repair proteins in mouse meiosisSemantic proximity Read ↗

CXXC1 is redundant for normal DNA double-strand break formation and meiotic recombination in mouseSemantic proximity Read ↗

A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.Semantic proximity Read ↗

Human RAD51 paralogue, SWSAP1, fosters RAD51 filament by regulating the anti-recombinase, FIGNL1 AAA+ ATPaseSemantic proximity Read ↗

From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis‐specific recombinase Dmc1Semantic proximity Read ↗

Disruption of dmc1 Produces Abnormal Sperm in Medaka (Oryzias latipes)Semantic proximity Read ↗

Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.Semantic proximity Read ↗

Genetic control of meiosis surveillance mechanisms in mammalsSemantic proximity Read ↗

<i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.