Article

Sexual dimorphism in the meiotic requirement for PRDM9: a mammalian evolutionary safeguard

2020-03-13

Abstract excerpt

In many mammals, genomic sites for recombination are determined by histone methyltransferase PRMD9. Mice lacking PRDM9 are infertile, but instances of fertility or semi-fertility in the absence of PRDM9 have been reported in mice, canines and a human female. Such findings raise the question of how the loss of PRDM9 is circumvented to maintain reproductive fitness. We show that genetic background and sex-specific m...

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Literature Corpus work: 360820a6-bbe3-5e3e-80ef-86b73db471a4
DOI: 10.1101/2020.03.10.985358

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