Article

The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loading

2023-05-18

Abstract excerpt

During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by homologous recombination (HR). A balanced activity of positive and negative RAD51/DMC1 regulators ensures proper recombination. Fidgetin-like 1 (FIGNL1) was previously shown to negatively regulate RAD51 in human cells. However, FIGNL1’s role during meio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35daebd1-297a-52fc-b082-4fda3d4b5bc6
DOI: 10.1101/2023.05.17.541096

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loadingDOI 10.1101/2023.05.17.541096Read

FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loadingSemantic proximity Read

FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombinationSemantic proximity Read

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restartSemantic proximity Read

Homologous recombinational repair proteins in mouse meiosisSemantic proximity Read

A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.Semantic proximity Read

CXXC1 is redundant for normal DNA double-strand break formation and meiotic recombination in mouseSemantic proximity Read

The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.Semantic proximity Read

From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis‐specific recombinase Dmc1Semantic proximity Read

Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.Semantic proximity Read

FIGNL1-containing protein complex is required for efficient homologous recombination repair.Semantic proximity Read

<i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammalsSemantic proximity Read

The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatinSemantic proximity Read