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Article

De novo deletions and duplications at recombination hotspots in mouse germlines

2020-06-23

Abstract excerpt

<h4>Summary</h4> Numerous DNA double-strand breaks (DSBs) arise during meiosis to initiate homologous recombination. These DSBs are usually repaired faithfully, but here we uncover a new type of mutational event in which deletions form via joining of ends from two closely spaced DSBs (double cuts) within a single hotspot or at adjacent hotspots on the same or different chromatids. Deletions occur in normal meiosi...

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Identifiers and source

Literature Corpus work
960d8a73-cd01-543e-99d3-2e82384e4d2a
DOI
10.1101/2020.06.23.168138
Open publication

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De novo deletions and duplications at recombination hotspots in mouse germlinesDOI 10.1101/2020.06.23.168138
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