Article

The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatin

2025-06-01

Abstract excerpt

<h4>SUMMARY</h4> During meiosis, a group of evolutionarily conserved ZMM proteins plays essential roles in stabilizing the recombination intermediates and promoting crossover (CO) formation. In mice, SHOC1 forms a trimeric complex with the other two ZMM proteins, SPO16 and TEX11, to bind recombination intermediates after strand invasion. Although genetic variants of SHOC1 are clinically associated with meiotic a...

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Literature Corpus work: 35b72f67-7e0d-5a54-9f9c-0497d19b4331
DOI: 10.1101/2025.05.28.656576

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