Article

H2AFX and MDC1 Protect Genomic Integrity in Male Germ Cells by Promoting Recombination and Activation of the Recombination-Dependent Checkpoint

2017-12-15

Abstract excerpt

In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage response. However, it is not known whether they are also involved in the maintenance of genome integrity in meiosis. By analyzing chromosome dynamics in H2afx -/- spermatocytes, we found that synapsis of the autosomes and X-Y chromosomes were impaired in a relevant fraction of cells. Such defect correlated with an abnormal...

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Literature Corpus work: 272d9232-3641-5993-9150-93c7bf58b959
DOI: 10.1101/235085

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