Article

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

2019-10-30

Abstract excerpt

During meiosis, homologous chromosomes pair (synapse) and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, recombination initiates with double-strand breaks (DSBs) within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising this unique combination of histone marks have yet been identified. We identified Zcwpw1 , which poss...

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Literature Corpus work: 46742bed-a065-5493-a548-d8cb0eee214b
DOI: 10.1101/821678

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