Article

A novel age-informative polygenic score improves predictive ability for kidney function and kidney function decline

2026-01-23

Abstract excerpt

Polygenic scores (PGSs) are widely used to summarize the joint genetic effects for disease-related traits. However, while age-dependent genetic effects are increasingly recognized, their integration into PGSs remains underexplored. Kidney function, assessed by estimated glomerular filtration rate (eGFR), has strong age-related genetic effects, and prediction of kidney function decline is an unmet need. We develop...

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Literature Corpus work: 84af39c2-3dcf-5fc2-a9cc-b1d255d64a5f
DOI: 10.64898/2026.01.22.26344420

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