Article

Polygenic Risk Scores for Kidney Function to the Circulating Proteome, and Incident Kidney Diseases: the Atherosclerosis Risk in Communities Study

2020-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have revealed numerous loci for kidney function (estimated glomerular filtration rate, eGFR). The relationship of polygenic predictors of eGFR, risk of incident adverse kidney outcomes, and the plasma proteome is not known. We developed a genome-wide polygenic risk score (PRS) using a weighted average of 1.2 million SNPs for eGFR using the LDpred algorithm,...

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Literature Corpus work: 49e9cf47-62d4-569c-b991-2495fc2f36b2
DOI: 10.1101/2020.09.05.284265

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