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Article

Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases.

Journal of the American Society of Nephrology : JASN - 1 Dec 2021

Yu Zhi, Jin Jin, Tin Adrienne, Köttgen Anna, Yu Bing, Chen Jingsha, Surapaneni Aditya, Zhou Linda, Ballantyne Christie M, Hoogeveen Ron C, Arking Dan E, Chatterjee Nilanjan, Grams Morgan E, Coresh Josef

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have revealed numerous loci for kidney function (eGFR). The relationship between polygenic predictors of eGFR, risk of incident adverse kidney outcomes, and the plasma proteome is not known. METHODS: We developed a genome-wide polygenic risk score (PRS) for eGFR by applying the LDpred algorithm to summary statistics generated from a multiethnic meta-analysis of...

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Identifiers

PMID: 34548389
DOI: 10.1681/ASN.2020111599
PMCID: PMC8638405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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