Article

Shared genetic architecture between inflammatory proteins and eGFR difference identifies chronic inflammation risk factors for kidney function impairment

2026-01-27

Abstract excerpt

<title>Abstract</title> <p>Chronic kidney disease(CKD) is linked to systemic inflammation, yet the shared genetic mechanisms remain unclear. Emerging evidence indicates that the difference between cystatin C- and creatinine-based eGFR serves as an early biological indicator capturing inflammatory, cardiometabolic, and mortality-related risk signals that precede subclinical kidney injury. Using large-scale cohorts...

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Literature Corpus work: aea8322b-76aa-5d46-b63f-23a8b17229ba
DOI: 10.21203/rs.3.rs-8627406/v1

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