Article
Genome-wide polygenic score to predict chronic kidney disease across ancestries.
Nature medicine - 1 Jul 2022
Khan Atlas, Turchin Michael C, Patki Amit, Srinivasasainagendra Vinodh, Shang Ning, Nadukuru Rajiv, Jones Alana C, Malolepsza Edyta, Dikilitas Ozan, Kullo Iftikhar J, Schaid Daniel J, Karlson Elizabeth, Ge Tian, Meigs James B, Smoller Jordan W, Lange Christoph, Crosslin David R, Jarvik Gail P, Bhatraju Pavan K, Hellwege Jacklyn N, Chandler Paulette, Torvik Laura Rasmussen, Fedotov Alex, Liu Cong, Kachulis Christopher, Lennon Niall, Abul-Husn Noura S, Cho Judy H, Ionita-Laza Iuliana, Gharavi Ali G, Chung Wendy K, Hripcsak George, Weng Chunhua, Nadkarni Girish, Irvin Marguerite R, Tiwari Hemant K, Kenny Eimear E, Limdi Nita A, Kiryluk Krzysztof
Abstract excerpt
Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; however, this approach has not been optimized for ancestrally diverse populations. By combining APOL1 risk genotypes with genome-wide association studies (GWAS) of kidney function, we designed, optimized and validated a genome-wide polygenic...
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