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Polygenic risk scores for eGFR are associated with age at kidney failure

3 Mar 2025

Abstract excerpt

BACKGROUND: The genetic architecture of chronic kidney disease (CKD) is complex, including monogenic and polygenic contributions. CKD progression to kidney failure is influenced by factors including male sex, baseline estimated glomerular filtration rate (eGFR), hypertension, diabetes, proteinuria, and the underlying kidney disease. These traits all have strong genetic components, which can be partially...

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PMID: 40029548
DOI: 10.1007/s40620-025-02207-7

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