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Article

Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline.

Nature communications - 20 Nov 2024

Wiegrebe Simon, Gorski Mathias, Herold Janina M, Stark Klaus J, Thorand Barbara, Gieger Christian, Böger Carsten A, Schödel Johannes, Hartig Florian, Chen Han, Winkler Thomas W, Küchenhoff Helmut, Heid Iris M

Abstract excerpt

Understanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. We use longitudinal UK Biobank data for creatinine-based estimated glomerular filtration rate from 348,275 individuals to search for genetic variants associated with eGFR-decline. This search was performed both among 595...

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Identifiers

PMID: 39567532
DOI: 10.1038/s41467-024-54483-9
PMCID: PMC11579025

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