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Article

Association of polygenic scores with chronic kidney disease phenotypes in a longitudinal study of older adults.

Kidney international - 1 Jun 2023

Bakshi Andrew, Jefferis Julia, Wolfe Rory, Wetmore James B, McNeil John J, Murray Anne M, Polkinghorne Kevan R, Mallett Andrew J, Lacaze Paul

Abstract excerpt

Risk of chronic kidney disease (CKD) is influenced by environmental and genetic factors and increases sharply in individuals 70 years and older. Polygenic scores (PGS) for kidney disease-related traits have shown promise but require validation in well-characterized cohorts. Here, we assessed the performance of recently developed PGSs for CKD-related traits in a longitudinal cohort of healthy older individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37001602
DOI: 10.1016/j.kint.2023.03.017
PMCID: PMC10200771

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