Article
Polygenic risk affects the penetrance of monogenic kidney disease
2023-05-10
Abstract excerpt
<h4>ABSTRACT</h4> <h4>Background</h4> Chronic kidney disease (CKD) is a genetically complex disease determined by an interplay of monogenic, polygenic, and environmental risks. Most forms of monogenic kidney diseases have incomplete penetrance and variable expressivity. It is presently unknown if some of the variability in penetrance can be attributed to polygenic factors. <h4>Methods</h4> Using the UK Biobank (N=...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- ad28e27a-5d62-51e2-b4c4-ef0d4bb63475
- DOI
- 10.1101/2023.05.07.23289614