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Article

Polygenic scores and their applications in kidney disease.

Nature reviews. Nephrology - 1 Jan 2025

Khan Atlas, Kiryluk Krzysztof

Abstract excerpt

Genome-wide association studies (GWAS) have uncovered thousands of risk variants that individually have small effects on the risk of human diseases, including chronic kidney disease, type 2 diabetes, heart diseases and inflammatory disorders, but cumulatively explain a substantial fraction of disease risk, underscoring the complexity and pervasive polygenicity of common disorders. This complexity poses unique...

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Identifiers

PMID: 39271761
DOI: 10.1038/s41581-024-00886-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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