Article

Reference-free multiplexed single-cell sequencing identifies genetic modifiers of the human immune response

2023-06-01

Abstract excerpt

Multiplexed single-cell sequencing (mux-seq) using single-nucleotide polymorphisms (SNPs) has emerged as an efficient approach to perform expression quantitative trait loci (eQTL) studies that map interactions between genetic variants and cell types, cell states, or experimental perturbations. Here we introduce the clue framework, a novel approach to encode mux-seq experiments that eliminates the need for referen...

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Literature Corpus work: 849d15b6-fea7-52f4-9159-af163e184756
DOI: 10.1101/2023.05.29.542756

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