Article

Single-cell RNA-sequencing reveals widespread personalized, context-specific gene expression regulation in immune cells

2021-06-06

Abstract excerpt

Gene expression and its regulation can be context-dependent. To dissect this, using samples from 120 individuals, we single-cell RNA-sequenced 1.3M peripheral blood mononuclear cells exposed to three different pathogens at two time points or left unexposed. This revealed thousands of cell type-specific expression changes (eQTLs) and pathogen-induced expression changes (response QTLs) that are influenced by genetic...

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Literature Corpus work: 752f3ba0-5288-5506-9d6f-349dc9a456fd
DOI: 10.1101/2021.06.04.447088

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