Article

Genetic variants associated with cell-type-specific intra-individual gene expression variability reveal new mechanisms of genome regulation

2024-05-07

Abstract excerpt

Gene expression levels can vary substantially across cells, even in a seemingly homogeneous cell population. Identifying the relationships between genetic variation and gene expression is critical for understanding the mechanisms of genome regulation. However, the genetic control of gene expression variability among the cells within individuals has yet to be extensively examined. This is primarily due to the stat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 900d26e8-3204-5c5c-bcd3-573d02b469f2
DOI: 10.1101/2024.05.05.592598

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic variants associated with cell-type-specific intra-individual gene expression variability reveal new mechanisms of genome regulationDOI 10.1101/2024.05.05.592598Read

Impact of rare and common genetic variation on cell type-specific gene expression in human bloodSemantic proximity Read

Genetic variants contribute to gene expression variability in humans.Semantic proximity Read

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infectionSemantic proximity Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell dataSemantic proximity Read

Genetic determinants of gene expression noise and its role in complex trait variationSemantic proximity Read

Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19.Semantic proximity Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.Semantic proximity Read

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read

Genetic determinants of gene expression noise and its role in complex trait variation.Semantic proximity Read

Identifying genetic variants that influence the abundance of cell states in single-cell dataSemantic proximity Read

Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels.Semantic proximity Read

Mapping interindividual dynamics of innate immune response at single-cell resolutionSemantic proximity Read