Article

Impact of rare and common genetic variation on cell type-specific gene expression in human blood

2025-03-21

Abstract excerpt

Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases. Single cell-resolved measures of RNA levels and single-cell expression quantitative trait loci (sc-eQTLs) have revealed genetic regulation that drives sub-tissue cell states and types across diverse human tissues. Here, we describe the first phase of TenK10K, the largest-to-date da...

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Literature Corpus work: 98a4e723-e847-567c-bb71-76cb30badf06
DOI: 10.1101/2025.03.20.25324352

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