Article

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast

2025-10-21

Abstract excerpt

The kinetochore is a multiprotein complex formed at the centromeres and is essential for the faithful chromosome segregation. In most of the organisms the kinetochore is assembled on a specialized centromeric nucleosome where histone H3 is replaced by a variant, named CENP-A. In budding yeast, the CENP-A homolog, Cse4 is recruited to the centromeric nucleosome through an interaction between its C-terminal domain a...

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Literature Corpus work: 848c7f0e-88c1-5790-b03d-ef91dcd5e15f
DOI: 10.1101/2025.10.20.683541

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