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Article

Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.

Molecular cell - 13 Feb 2009

Pidoux Alison L, Choi Eun Shik, Abbott Johanna K R, Liu Xingkun, Kagansky Alexander, Castillo Araceli G, Hamilton Georgina L, Richardson William, Rappsilber Juri, He Xiangwei, Allshire Robin C

Abstract excerpt

The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human. Fission yeast sim1 mutants that alleviate kinetochore domain silencing are defective in Scm3(Sp), the ortholog of budding yeast Scm3(Sc). Scm3(Sp) depends on Mis16/18 for its centromere...

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Identifiers

PMID: 19217404
DOI: 10.1016/j.molcel.2009.01.019
PMCID: PMC2697330

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Related research

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Research trail→

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Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.PMID 19217404Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.Semantic proximity Read ↗

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.Semantic proximity Read ↗

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeastSemantic proximity Read ↗

Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathwaySemantic proximity Read ↗

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.Semantic proximity Read ↗

Scm3 is a centromeric nucleosome assembly factor.Semantic proximity Read ↗

Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.Semantic proximity Read ↗

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.Semantic proximity Read ↗

CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.Semantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.Semantic proximity Read ↗

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