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Article

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2007

Stoler Sam, Rogers Kelly, Weitze Scott, Morey Lisa, Fitzgerald-Hayes Molly, Baker Richard E

Abstract excerpt

A universal mark of centromeric chromatin is its packaging by a variant of histone H3 known as centromeric H3 (CenH3). The mechanism by which CenH3s are incorporated specifically into centromere DNA or the specialized function they serve there is not known. In a genetic approach to identify factors involved in CenH3 deposition, we screened for dosage suppressors of a temperature-sensitive cse4 allele in...

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Identifiers

PMID: 17548816
DOI: 10.1073/pnas.0703178104
PMCID: PMC1885823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.PMID 17548816Read ↗

The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.Semantic proximity Read ↗

Analysis of primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3.Semantic proximity Read ↗

Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Scm3 is a centromeric nucleosome assembly factor.Semantic proximity Read ↗

The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeastSemantic proximity Read ↗

The overexpression of a Saccharomyces cerevisiae centromeric histone H3 variant mutant protein leads to a defect in kinetochore biorientation.Semantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

Cse4 is part of an octameric nucleosome in budding yeast.Semantic proximity Read ↗

A role for CENP-A/Cse4 phosphorylation on serine 33 in deposition at the centromere.Semantic proximity Read ↗

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