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Article

Scm3 is a centromeric nucleosome assembly factor.

The Journal of biological chemistry - 8 Apr 2011

Shivaraju Manjunatha, Camahort Raymond, Mattingly Mark, Gerton Jennifer L

Abstract excerpt

The Cse4 nucleosome at each budding yeast centromere must be faithfully assembled each cell cycle to specify the site of kinetochore assembly and microtubule attachment for chromosome segregation. Although Scm3 is required for the localization of the centromeric H3 histone variant Cse4 to centromeres, its role in nucleosome assembly has not been tested. We demonstrate that Scm3 is able to mediate the assembly of...

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Identifiers

PMID: 21317428
DOI: 10.1074/jbc.M110.183640
PMCID: PMC3069404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Scm3 is a centromeric nucleosome assembly factor.PMID 21317428Read ↗

Cse4 is part of an octameric nucleosome in budding yeast.Semantic proximity Read ↗

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeastSemantic proximity Read ↗

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.Semantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

Recognition of the centromere-specific histone Cse4 by the chaperone Scm3.Semantic proximity Read ↗

The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.Semantic proximity Read ↗

The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.Semantic proximity Read ↗

Analysis of primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3.Semantic proximity Read ↗

Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.Semantic proximity Read ↗

CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.Semantic proximity Read ↗

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