Article

Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway

2024-07-27

Abstract excerpt

The centromeric protein-A (CENP-A) is an evolutionary conserved histone H3 variant that marks the identity of the centromeres. Several mechanisms regulate the centromeric deposition of CENP-A as its mislocalization causes erroneous chromosome segregation, leading to aneuploidy-based diseases, including cancers. The most crucial deposition factor is a CENP-A specific chaperone, HJURP (Scm3 in budding yeast), which...

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Literature Corpus work: 7f0d16bc-8290-5e40-8a38-f33342cad167
DOI: 10.1101/2024.07.26.605363

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