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Article

The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.

Eukaryotic cell - 1 Dec 2004

Morey Lisa, Barnes Kelly, Chen Yinhuai, Fitzgerald-Hayes Molly, Baker Richard E

Abstract excerpt

Centromere-specific H3-like proteins (CenH3s) are conserved across the eukaryotic kingdom and are required for packaging centromere DNA into a specialized chromatin structure required for kinetochore assembly. Cse4 is the CenH3 protein of the budding yeast Saccharomyces cerevisiae. Like all CenH3 proteins, Cse4 consists of a conserved histone fold domain (HFD) and a divergent N terminus (NT). The Cse4 NT contains...

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Identifiers

PMID: 15590827
DOI: 10.1128/EC.3.6.1533-1543.2004
PMCID: PMC539035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.PMID 15590827Read ↗

The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.Semantic proximity Read ↗

Analysis of primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3.Semantic proximity Read ↗

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

Cse4 is part of an octameric nucleosome in budding yeast.Semantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

The overexpression of a Saccharomyces cerevisiae centromeric histone H3 variant mutant protein leads to a defect in kinetochore biorientation.Semantic proximity Read ↗

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.Semantic proximity Read ↗

An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain.Semantic proximity Read ↗

A role for CENP-A/Cse4 phosphorylation on serine 33 in deposition at the centromere.Semantic proximity Read ↗

CSE4 genetically interacts with the Saccharomyces cerevisiae centromere DNA elements CDE I and CDE II but not CDE III. Implications for the path of the centromere dna around a cse4p variant nucleosome.Semantic proximity Read ↗

Scm3 is a centromeric nucleosome assembly factor.Semantic proximity Read ↗

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