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Article

Recognition of the centromere-specific histone Cse4 by the chaperone Scm3.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011

Cho Uhn-Soo, Harrison Stephen C

Abstract excerpt

A specialized nucleosome is a component of all eukaryotic kinetochores. The core of this nucleosome contains a centromere-specific histone, CENP-A (the Cse4 gene product in budding yeast), instead of the usual H3. Assembly of a centromeric nucleosome depends on a specific chaperone, called Scm3 in yeast and HJURP in higher eukaryotes. We describe here the structure of a complex formed by an N-terminal fragment of...

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Share to Centromere
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21606327
DOI: 10.1073/pnas.1106389108
PMCID: PMC3111289

Genes

HJURP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Recognition of the centromere-specific histone Cse4 by the chaperone Scm3.PMID 21606327Read ↗

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeastSemantic proximity Read ↗

Scm3 is a centromeric nucleosome assembly factor.Semantic proximity Read ↗

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Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.Semantic proximity Read ↗

CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.Semantic proximity Read ↗

Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathwaySemantic proximity Read ↗

The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.Semantic proximity Read ↗

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