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Article

Cse4 is part of an octameric nucleosome in budding yeast.

Molecular cell - 24 Sept 2009

Camahort Raymond, Shivaraju Manjunatha, Mattingly Mark, Li Bing, Nakanishi Shima, Zhu Dongxiao, Shilatifard Ali, Workman Jerry L, Gerton Jennifer L

Abstract excerpt

The budding yeast CenH3 histone variant Cse4 localizes to centromeric nucleosomes and is required for kinetochore assembly and chromosome segregation. The exact composition of centromeric Cse4-containing nucleosomes is a subject of debate. Using unbiased biochemical, cell-biological, and genetic approaches, we have tested the composition of Cse4-containing nucleosomes. Using micrococcal nuclease-treated...

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Identifiers

PMID: 19782029
DOI: 10.1016/j.molcel.2009.07.022
PMCID: PMC2757638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cse4 is part of an octameric nucleosome in budding yeast.PMID 19782029Read ↗

Scm3 is a centromeric nucleosome assembly factor.Semantic proximity Read ↗

Analysis of primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3.Semantic proximity Read ↗

The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.Semantic proximity Read ↗

The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.Semantic proximity Read ↗

An asymmetric centromeric nucleosome.Semantic proximity Read ↗

CSE4 genetically interacts with the Saccharomyces cerevisiae centromere DNA elements CDE I and CDE II but not CDE III. Implications for the path of the centromere dna around a cse4p variant nucleosome.Semantic proximity Read ↗

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.Semantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

Recognition of the centromere-specific histone Cse4 by the chaperone Scm3.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-microm circle partitioning locus and promotes equal plasmid segregation.Semantic proximity Read ↗

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeastSemantic proximity Read ↗

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