Article
De novo kinetochore assembly requires the centromeric histone H3 variant.
Molecular biology of the cell - 1 Dec 2005
Collins Kimberly A, Castillo Andrea R, Tatsutani Sean Y, Biggins Sue
Abstract excerpt
Kinetochores mediate chromosome attachment to the mitotic spindle to ensure accurate chromosome segregation. Budding yeast is an excellent organism for kinetochore assembly studies because it has a simple defined centromere sequence responsible for the localization of >65 proteins. In addition, yeast is the only organism where a conditional centromere is available to allow studies of de novo kinetochore assembly....
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