Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.

The Journal of cell biology - 28 Apr 2003

Pidoux Alison L, Richardson William, Allshire Robin C

Abstract excerpt

Fission yeast centromeres are composed of two domains: the central core and the outer repeats. Although both regions are required for full centromere function, the central core has a distinct chromatin structure and is likely to underlie the kinetochore itself, as it is associated with centromere-specific proteins. Genes placed within either region are transcriptionally silenced, reflecting the formation of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Centromere
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Segregation

Share to Gene Silencing

Share to Kinetochores

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Silencer Elements, Transcriptional

Source

Open in PubMed Open full text

Identifiers

PMID: 12719471
DOI: 10.1083/jcb.200212110
PMCID: PMC2172903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.PMID 12719471Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.Semantic proximity Read ↗

Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.Semantic proximity Read ↗

A new role for the transcriptional corepressor SIN3; regulation of centromeres.Semantic proximity Read ↗

Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein.Semantic proximity Read ↗

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.Semantic proximity Read ↗

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.Semantic proximity Read ↗

The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Semantic proximity Read ↗

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.Semantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeastSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.