Article

<i>SigRescueR</i> : A Pan-System Framework for Noise Correction and Mutational Signature Identification Across Sequencing Platforms

2025-11-15

Abstract excerpt

Mutational signatures serve as molecular fingerprints of the biological processes and exposures that shape cancer genomes. However, accurate signal recovery remains challenging due to pervasive background variants, sequencing artifacts, technical noise, and platform-specific biases that obscure true mutagenic patterns, hampering biomarker discovery and mechanistic interpretation. Here we introduce SigRescueR , a...

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Literature Corpus work: 84867d86-329c-560e-8abf-f0f8b4352f79
DOI: 10.1101/2025.11.14.688578

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