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Article

SigRescueR: a pan-system framework for noise correction and mutational signature identification across sequencing platforms.

Briefings in bioinformatics - 1 Mar 2026

Nguyen Peter T, Zhivagui Maria

Abstract excerpt

INTRODUCTION: Mutational signatures serve as molecular fingerprints of the biological processes and exposures that shape cancer genomes. However, accurate signal recovery remains challenging due to pervasive background variants, sequencing artifacts, technical noise, and platform-specific biases that obscure true mutagenic patterns, hampering biomarker discovery, and mechanistic interpretation. METHODS: Here we...

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PMID: 41789568
DOI: 10.1093/bib/bbag099
PMCID: PMC12963972

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