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Article

Mutational signatures are markers of drug sensitivity of cancer cells.

Nature communications - 25 May 2022

Levatić Jurica, Salvadores Marina, Fuster-Tormo Francisco, Supek Fran

Abstract excerpt

Genomic analyses have revealed mutational footprints associated with DNA maintenance gone awry, or with mutagen exposures. Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. We detect mutational signatures in cancer cell line exomes (where matched healthy tissues are not available) by adjusting for the confounding germline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35614096
DOI: 10.1038/s41467-022-30582-3
PMCID: PMC9132939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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