Article
DNA Repair Footprint Uncovers Contribution of DNA Repair Mechanism to Mutational Signatures.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2020
Wojtowicz Damian, Leiserson Mark D M, Sharan Roded, Przytycka Teresa M
Abstract excerpt
Cancer genomes accumulate a large number of somatic mutations resulting from imperfection of DNA processing during normal cell cycle as well as from carcinogenic exposures or cancer related aberrations of DNA maintenance machinery. These processes often lead to distinctive patterns of mutations, called mutational signatures. Several computational methods have been developed to uncover such signatures from...
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