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Article

Exploring background mutational processes to decipher cancer genetic heterogeneity.

Nucleic acids research - 3 Jul 2017

Goncearenco Alexander, Rager Stephanie L, Li Minghui, Sang Qing-Xiang, Rogozin Igor B, Panchenko Anna R

Abstract excerpt

Much remains unknown about the progression and heterogeneity of mutational processes in different cancers and their diagnostic and clinical potential. A growing body of evidence supports mutation rate dependence on the local DNA sequence context for various types of mutations. We propose several tools for the analysis of cancer context-dependent mutations, which are implemented in an online computational...

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PMID: 28472504
DOI: 10.1093/nar/gkx367
PMCID: PMC5793731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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