Article
Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing.
Cell reports - 23 Jun 2026
Kucab Jill E, Nandi Shuvro P, Al-Serori Halh, Dunstone Ellie, Beck Rebekah S S, Caipa Garcia Angela L, Wilde Eleanor C, Saeed Safa, Francies Hayley, Garnett Mathew J, Fu Beiyuan, Yang Fengtang, Saeb-Parsy Kourosh, Huch Meritxell, Drost Jarno, Zilbauer Matthias, Humphreys Laura, Kisby Glen, Arlt Volker M, Stratton Michael R, Alexandrov Ludmil B, Phillips David H
Abstract excerpt
Environmental exposures play a pivotal role in carcinogenesis, yet their molecular imprints in human tissues remain incompletely understood. Here, we present an extensive catalog of mutational signatures induced by a panel of environmental carcinogens using human tissue-derived organoids coupled with high-fidelity duplex sequencing (NanoSeq). This unique combination enables direct detection of mutations without...
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